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KMID : 0359920090280060685
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Korean Journal of Nephrology
2009 Volume.28 No. 6 p.685 ~ p.692
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Successful Treatment of Sclerosing Encapsulating Peritonitis with Tamoxifen and Prednisolone
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Jung Ji-Yoon
Jang Won-Ik
Yoon Ji-Hyun
Kim Eui-Sik
Chung Sa-Rah
Choi Dae-Eun
Na Ki-Ryang
Lee Kang-Wook
Kang Dae-Young
Shin Young-Tai
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Abstract
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Sclerosing encapsulating peritonitis (SEP) is an uncommon but serious complication of long-term peritoneal dialysis (PD). Entrapment of the intestine in fibrous tissue, causing complete intestinal obstruction, is referred to as SEP. The usual clinical presentation is with partial or complete small bowel obstruction, ascites, abdominal mass, or impaired peritoneal ultrafiltration. Conservative treatment carries a poor outcome and surgery has offered variable results. Even though there is no established medical treatment, immunosuppressive drugs, steroid and tamoxifen are often used. Tamoxifen is a nonsteroidal anti-estrogenic drug commonly used in the management of breast cancer. To our knowledge, this is the first case of sclerosing encapsulating peritonitis successfully treated with tamoxifen and prednisolone in Korea. Recently, we have treated three SEP patients with tamoxifen and prednisolone. All three patients showed clinical improvement within a few months.
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KEYWORD
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Tamoxifen, Peritonitis, Peritoneal dialysis
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